Endocrine Abstracts

: Autoimmune polyglandular syndrome (APS) type 3 – is a rare orphan disease, which is a combination of autoimmune thyroid disease and diabetes mellitus (DM) type 1 and/or pernicious anemia, vitiligo, alopecia. Due to the rare occurrence in pediatric patients we give our own observation of early manifestation of APS type 3 A in a girl 10 years. Complaints in the primary treatment: sweating, irritability, cardiopalmus, weight loss. Survey results: ultrasound examination of ...

Pseudohypoaldosteronism is one of the least explored questions in clinical endocrinology. That leads to complexity in diagnosis and differential diagnostics of disease. A boy, aged 13 days was admitted to the hospital with complains: vomiting, low weight gain, constipation. Biochemical blood assay (BBA) and acid-base balance of blood: level of sodium −127 mmol/l (N 132 – 145 mmol/l), potassium −6.6 mmol/l (N 3.1 – 5.1 mmol/l), chlorine &...

Medical History of thirty five patients aged from one to sixteen years diagnosed with CAH have been analyzed in the Republican Center for Pediatric Endocrinology. Among the thirty five patients participating in the study (boys–fifty seven percent, girls –forty-three) seventy-one percent is with salt wasting form (SWF), twenty-two percent with virilising form (VF), three percent with non-classical form (NF). The mean weight SDS at birth is minus eight hund...

Objective: to assess the effects of associated autoimmune diseases on diabetes control, growth, lipid profile in children with type 1 diabetes mellitus (T1DM) and to determine the most predictive genetic, immune and metabolic risk factors of polyglandular autoimmunity in children with T1DM.Material and Methods: 89 children with combined autoimmune pathology (main group, age 11.82 ± 3.68 years) and 100 patients with isolated T1DM (control group, age ...

Aim: Evaluate the data of anamnesis, clinical-laboratory parameters, magnetic resonance imaging (MRI) findings, response to treatment in children with hyperprolactinemia (HProlact).Methods: We analyzed retrospectively 16 patients in the endocrinological department of University hospital (Minsk) with HProlact over 2004–2012 years. Boys (B) 6 (37.5%) (stage on Tanner 1 – 1 (17%); stage 2–3 – 3 (50%), stage 4 – 2 (33%), age at diagn...

Aim: The aim of our study was to evaluate the effectiveness of the body mass (BM) decreasing program in pubertal children with alimentary obesity during the year of observation.Materials and methods: Anthropometric changes in body mass index (BMI) and waist circumflex (WC) were analyzed every 1, 3, 6 and 12 months in 100 obese pubertal children (boys/girls =50/50) with different treatment methods: the 1st group – only reducing diet (b/g=30/30), the ...

Poor family functioning will be associated with inadequate parental monitoring and/or regulation of children’s eating and activity patterns. We aimed to examine the relationship between a child’s weight and a broad rang of family and maternal factors. Our hypothesis was that increasing adiposity in children would be associated with poor general family functioning, lower socioeconomic status, inappropriate parenting style. This cross-sectional study involved 56 obese ...

ObjectiveTo determine predictive factors of co-existing autoimmunity in children with type 1 diabetes mellitus (T1D).Material and methods64 children with combined autoimmune pathology (T1D and autoimmune thyroid diseases or celiac disease) - main group, age 12.14±3.54 years) and 81 patients with only T1D (comparison group, age 11.57±3.34 years) were recruited. Groups were comparable in age (P</e...

Objective: Determination of changes in metabolic status and vitamin D, osteoprotegerin concentrations in obese children.Methods: We examined 212 children in the University Hospital from 2016 to 2018 yrs. Their anthropometric parameters (body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. In the biochemical blood test, the parameters of uric acid, glucose were evaluated. All children were divided into 2 groups:...

Objectives: To evaluate the efficacy of growth hormone (GH) treatment in children with Turner syndrome (TS) and to analyze the factors affecting the success of treatment.Methods: Retrospective observational study was conducted for 62 patients with TS. 3 groups of patients were identified: group 1 with karyotype 45, X (n=32), group 2 with mosaic variant 45,X/46,XX (n=8), group 3 with structural anomalies of X chromosome (n=22). ...